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TIL products are typically polyclonal, enriched for CD8 + T cells, and contain clonally expanded populations recognizing multiple autologous tumor epitopes, including neoantigens, which likely underlies the depth and durability of clinical responses [74, 76]

The novel -aspartyl transferase activity of PsGGT was applied for the synthesis of L--aspartyl hydroxamate (BAH) using 80 mM L-asparagine (donor substrate) and 40 mM hydroxylammonium chloride (acceptor substrate) with 0.106 mM product yield (Prihanto et al., 2015b)

Zhu F, Ren Z

Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels