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However, there also appears to be a specialized testes- specific isoform of TXNR (5, 25), which supports the importance of Se-containing antioxidant enzymes to testicular function and health

Additionally, the role of non-classical ferroptosis suppressors (e.g., FSP1, DHODH, and GCH1/BH4) in ADPKD is entirely unexploredwhether these pathways compensate for GPX4 downregulation in cystic kidneys or if their dysfunction exacerbates ferroptosis susceptibility remains unknown, limiting the development of multi-targeted interventions

Kroemer, was an employee of Sanofi and now consults for Boehringer Ingelheim

This combination of features might accelerate and de-risk biopharmaceutical development by bridging early discovery to full-scale manufacturing under a single platform