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Investigating Liver Detoxification and Methylation A targeted history and laboratory assessment may help distinguish excessive exposure from impaired methylation, elevated SAH, poor transsulfuration, low glutathione, biliary dysfunction or gut-derived toxic burden

Another interesting strategy is the use of GzmB variants that are resistant to Sb9-mediated inhibition

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But high levels of vitamin E can potentially lead to dangerous effects by a disruption of the oxidative stress detoxification chain (Abudu et al., 2004)