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Increased susceptibility in Hp knockout mice during acute hemolysis

Due to neurons having a limited capacity for GSH synthesis, they must rely on astrocytes to supply precursors such as cysteine (Prez-Sala D and Pajares, 2023)

To preserve or restore the barrier, possible strategies include pairing mucolytics with hydrating agents (such as hypertonic saline or surfactants) and developing synthetic mucus mimetics or hydrogels