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A striking selectivity for AR binding sites based on the presence of adjacent binding motifs emerged in studies in which SUMO2 and 3 activity was inhibited pharmacologically: SUMOylation inhibition using ML-792 inhibited AR binding to genomic regions that contain multiple AREs, but enhanced AR binding to less accessible AREs that are enriched for pioneering transcription factor binding sites

E., Ciaraldi, T

The researchers observed that 7 g/kg/BW/day MeHg and above significantly increased SBP relative to control, while 14 g/kg/BW/day MeHg and above significantly increased diastolic blood pressure (DBP) relative to control

Many studies in the past have supported the relevance of these categories in relation to paroxysmal disorders beyond CVS