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Additionally, mitochondrial ROS-induced oxidation of GSDMD is a crucial mechanism facilitating GSDMD cleavage, which in turn drives NLRP3-dependent pyroptosis in macrophage [144]

Exclusive antagonism of the 4 7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates

L-Glutathione is a naturally occurring antioxidant compound studied for its role in oxidative stress balance, cellular detoxification pathways, and overall cellular health in clinical research