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Therefore, the use of an anti-CD38 antibody could be an interesting strategy to restore the anti-tumor immune response by acting on MDSCs [54]

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More so, as stated in this 2019 study, "there is no established upper limit for vitamin B12 intake, as it has a low potential for toxicity." Although taking extremely high dosages of vitamin B12 is deemed safe, it is still not recommended to go above and beyond recommended vitamin B12 intake levels as mentioned above

Symptoms of B12 deficiency B12 deficiency produces symptoms that overlap frustratingly with common tirzepatide side effects : Fatigue and low energy : Often attributed to reduced caloric intake Brain fog and poor concentration : Mistaken for a dietary side effect Mood changes : Depression, irritability, anxiety Tingling in hands or feet : Peripheral neuropathy from B12 depletion Weakness : Often blamed on muscle-related side effects Because these symptoms mirror common GLP-1 side effects, B12 deficiency often goes unrecognized in people taking tirzepatide