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Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B 12deficiency

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CD38 enzymatic activity also leads to extracellular adenosine production, which is immunosuppressive and may contribute to immune system evasion by tumor cells [5, 10]

(III.2.F) EXVIVO STUDY Ex vivo study on goat sublingual mucosa shows increase in permeation of drug through mucosa than that of In vitro condition because chitosan is able to break tight junction hence facilitate the passage of drug through this route .On the other hand PG will increase the pore size of the membrane along with alcohol as a result increase in Para-cellular movement of the drug .Therefore Ex- vivo data will help to predict In- vivo permeation pattern of the formulation