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Genes related to cytotoxicity were expressed on both Rej and nave subsets with no noticeable differences, while exhaustion markers were preferentially expressed on Rej liver(Fig B)

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The cardioprotective effects observed in vitro were confirmed in the study by Wang and colleagues, who demonstrated that daily administration of the sodium salt NaHS (80 M/day, intraperitoneally, for up to 12 weeks) significantly prevented the impairment in left ventricular systolic and diastolic functions, mitochondrial alterations (i.e., enlargement of organelles), and cardiomyocytes apoptosis in rats with HHcy induced by L-Met (2 g/kg/day, dissolved in 2.5% starch, by gavage, for 18 weeks) [131]

Neurosci Lett 471:134138 Dufy L, Roach P, Naumovski N (2015) Green tea catchins as neuroprotective agents: systematic review of the literature in animal pre-clinical trials