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Others include autoimmune hepatitis, hemolytic anemia, celiac disease (gluten intolerance), sarcoidosis (characterized by lumps of inflammatory cells throughout the body), and myasthenia gravis (characterized by weakness of voluntary muscles)

Of note, this marker of tissue repair is also characteristic of the intermediate, plastic state of OSKM reprogramming in vivo in the colon, as well as in the stomach and the pancreas 19

Kidney failure and liver damage: Untill now, studies in patients with liver damage or renal failure did not detect pharmacokinetic differences, in normal individuals

UK guidance typically recommends: Loading doses of colecalciferol (e.g., total of approximately 300,000 IU over 6-10 weeks) for confirmed deficiency Maintenance therapy with 8002,000 IU daily thereafter Higher doses may be required for malabsorption conditions Before starting high-dose vitamin D, check corrected calcium and renal function