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Of these, 74.7% were aware of their condition, 70.9% received antidiabetic treatment, and only 32.4% achieved glycosylated hemoglobin (HbA1c) 50%, and 15%25% of patients with diabetes experience neuropathic pain, referred to as painful DPN. Appropriate treatment of painful DPN is important because this pain contributes to a poor quality of life by causing sleep disturbance, anxiety, and depression

Despite extensive advances in elucidating ABA signaling in Arabidopsis , significant knowledge gaps remain

Dysfunctions of protein quality control systems such as the autophagy-lysosomal system are well demonstrated in SOD1 G93A mice and ALS patients 41, 42