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Antonoff MB , Swanson JA, Green CA, Mann BD, Maddaus MA, D'Cunha J

One was due to electrolyte imbalance caused by frequent enema administration [24], and the other was due to septicemia in a patient with terminal stage breast cancer and severely compromised hepatic function and immunity [25]

From the other side, patient who responds well to one TNF antagonist, however has a pharmacokinetic loss of response will benefit from another anti-TNF drug [68] and in cases of failure of the first-line therapy, a switch out of class is then recommended