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They have a dual role in biological systems, both beneficial than harmful depending on their nature and concentration as well as location and length of exposure ( Reactive Oxygen Species and Testis Mechanistic Antioxidative and Redox Defense Reactive oxygen species are involved in all cell physiological processes

Vitamin E plays a protective role in the pathological process of LLD via two mechanisms: first, it suppresses the expression of apoptosis-related molecules such as caspase-3, preserving neuronal structural integrity

Half-life & duration of action : Two-compartment model with an initial half-life of 4-5 hours followed by a terminal half-life of 25-36 hours

Catale C, Gironda S, Lo Iacono L, Carola V