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In such combinations, attenuated Salmonella functions as a T cell recruiter to convert an immunologically cold tumor into hot, while checkpoint inhibitors enhance the survival and activity of the infiltrating effector cells ( 5 Attenuation strategies: engineering a safe bacterial chassis Although the profound TME remodeling and immune activation described above will be responsible for therapeutic efficacy, it could also lead to systemic toxicity

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[99] It emerged as the third highest-grossing Indian film of all time

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