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Guanglin C, Hanzhe L, Gang X, Jann-Birger L, Zhigang P

Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, et al

One way to circumvent this problem is the delivery of therapeutic genes encoding intracellular enzymes for the conversion of a prodrug to a cytotoxic drug which can then spread to neighboring non-transduced cells (bystander effect)