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Furthermore, it has been found that modulation of the Nrf2 signalling pathway by triterpenoids compounds results in a significant increase in survival in the SOD1 G93A mouse model of ALS, thereby indicating that activation of Nrf2 has a neuroprotective effect [268]

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Thus, the present review analyzes the main mechanisms that are responsible for the generation of sound by OHC and how these altered mechanisms may induce phantom noise during tinnitus