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Accordingly, cellular oxidative stress is facilitated by the iron-catalyzed Fenton reaction and the degradation of lipid-derived alkoxy and peroxy radicals, and PD brains have a relatively high concentration of iron in the substantia nigra

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As a result, there is an initial, suppressed interferon response in early stage of infection

Notably, whereas PPAR agonism increases plasma HDL in humans, this is not the case in most applied rat and mouse models, as they lack the PPAR response element in the promotor region of ApoA1 (the major apolipoprotein of HDL)