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The need to schedule vitamin B12 injections is an avoidable addition to the cost and complexity of their care

Using metabolic markers of B12 status like methylmalonic acid and homocysteine to aid in the diagnosis of clinically manifested vitamin B12 deficiency has advantages, but also shortcomings [10,11], such as the high costs of measurements, the limited availability, and the impact of renal insufficiency on the concentrations

FDA advisers vote for looser rules

Indeed, as current in vitro and in vivo toxicity testing methods are mainly used to evaluate the acute and subacute toxicity of metal-based NPs, nanotoxicity testing methods for chronic long-term NPs exposure, which are crucial for predicting chronic toxicity in humans, are still lacking