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Immunotherapy treatment Mice ( n = 60) were placed on DIO diet for 15 weeks and then were randomized to orthotopic injection with 5 10 4 metM-Wnt lung cells containing either an shRNA construct targeting GPX4 ( n = 30 mice) or a scramble shRNA construct ( n = 30 mice)

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Targeting metabolic dysregulation for fibrosis therapy

Based on overall rates of missense variation [71, 72], we might expect every individual to carry roughly 510 missense alleles in these enzymes on average