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Ferroptosis: when metabolism meets cell death

Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cells antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment (40)

Dubrovsky, A

Chemical reactions, mechanisms of antioxidant enzyme activity, enzyme-related diseases (cancer, cardiovascular, lung, metabolic, and neurological diseases), and potential therapeutic applications of enzyme mimics and nanozymes are discussed