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Both doses of alpha-lipoic acid moderately decreased self-reported pain compared to baseline, with somewhat better results at the higher dose, while there was no decrease in pain with placebo

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however, processing enormous volumes of raw data, challenges in recognizing and characterizing unknown small molecules, dependence on the platforms inherent analytical coverage, and bias towards the detection of high-abundance compounds are the key drawbacks of untargeted metabolomics (Roberts et al., 2012