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Arzneimittel-Forschung 62 (07): 324329

However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)

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IGF-1 LR3 is a modified analogue with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension that reduces binding to IGF-binding proteins and extends half-life in research models