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10.1371/journal.pone.0119479 PLoS One 76 LiaoY.TangJ.MaM.WuZ.YangM.WangX

Large amounts of DAMPs, including cytokines and inflammatory modulators released from glioma cells that undergo ferroptosis, evokes an intense dysfunctional immune response and recruits numerous immune cells[176]

Consistently, NAD + deficiency leads to an impaired DDR and an increased genomic instability, suggesting an interplay between genomic stability and NAD + metabolism

Abstract Multiple sclerosis (MS) is a neurodegenerative condition that results in axonal and permanent damage to the central nervous system, necessitating healing owing to autoimmune reactions and persistent neuroinflammation