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Drug sensitivity analysis further demonstrated that patients in the high and low gene score groups exhibited significant differences in sensitivity to various anticancer agents ( Figure 10G )

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Though the antioxidant capacity of Lip-1 is well established [103], researchers have also implicated NRF2 upregulation [106], LPCAT3 and 15-LOX inhibition [107], and GPX4 and GSH upregulation [100] as core mechanisms of radioprotection by Lip-1