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SKU: 66648273597
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Xiao Z, Deng S, Liu H, Wang R, Dai Z,Gu W,Ni Q

Yang M, Wang Z, Xie J, Reyad-Ul-Ferdous M, Li S, Song Y

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

Permeability studies on Caco-2 and hCMEC/D3 cell monolayers showed enhanced intestinal and brain permeability of the encapsulated drug, with a 3.4-fold increase in coumarin transport across intestinal cells and a 25.6% increase in BBB permeability