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222 In addition, the overexpression of other components of the -secretase complex, including nicastrin, anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (Pen 2), also suppresses p53 expression in AD animal models

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Previous reports have documented many molecules have effects in influencing oxidative stress and ferroptosis (Table 2)

Additionally, there are two hydrophobic regions (H7 and H8), which contribute to van der Waals interactions and play a role in the binding affinity