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From a molecular viewpoint, key mechanistic themes have emerged: microbial metabolites such as SCFAs, tryptophan metabolites, and bile acids can penetrate into the CNS or signal via the vagus, modulating microglial activation, astrocytic support, and even neuronal gene expression

Pre-clinical models of emphysema induced with oxidant stress and/or protease-dependent lung damage have also provided insights into the potential for antioxidants as therapies

Much like BRD4 ET , MLL4 PHD2/3 recognized ASXL1 EBM-MBH and ASXL1 MBH almost equally well (Fig

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