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5) and can be started regardless of the type of enzyme deficiency underlying the urea cycle [38, 39], the goal of treatment being to reduce ammonia production and accelerate elimination via alternative pathways (Fig

However, as we noted in the FY 2022 IPPS/LTCH PPS proposed rule (86 FR 25344) and FY 2023 IPPS/LTCH proposed rule (87 FR 28295), in the CONFIRM trial, while the proportion of patients with verified HRS reversal without HRS recurrence by Day 30 was numerically greater in the TERLIVAZ group than placebo, the difference between groups was not statistically significant (26% vs 17%, p=0.08)

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Your body naturally produces short chains of amino acids called peptides