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For instance, curcumin has been found to stimulate the expression of glutamate-cysteine ligase , the enzyme responsible for initiating glutathione synthesis

These observations are usually mild and manageable in research settings but they highlight the importance of monitoring and adjusting research protocols as needed

5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action

SD, RD, and ZS are employees of Lonza, while KJ is a consultant to Lonza