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Predictive biomarkers, particularly those linked to key regulatory axes such as NRF2/p62, COX7A1 or USP13, require urgent discovery and clinical validation to reliably predict sensitivity to ferroptosis inducers or autophagy modulators

doi: 10.1021/acs.chemrestox.6b00147 47 TavernaM.MarieA

Moreover, TGF--induced metabolic reprogramming leads to increased glutaminolysis and serine/glycine synthesis, essential for collagen production and myofibroblast differentiation

Here, we used our recently established OCCT to measure TMAO productivity in 56 individuals who received carnitine supplementation for 1 month (Fig