glutathione synthetase deficiency schizophrenia Glial cell deficits are a key feature of schizophrenia: implications for neuronal circuit maintenance and histological differentiation from classical neurodegeneration Caught in vicious circles: a

Ethics declarations Ethics approval and consent to participate All animal studies were accredited by the Institutional Ethics Committee and followed the requirements for the care and use of laboratory animals of the Hangzhou Institute of Medicine (HIM) of the Chinese Academy of Sciences (AP2025-11-0636)

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Pillai A, Terry AV, Mahadik SP

According to the results of the Rosetta Cartesian_ddG and Flex_ddG, we manually checked the PV2 and PV3 variants predicted to be highly stable, exhibit low binding free energy and are located outside the CDR regions, and those having pAcF facing outward were selected for experimental characterization, including PV2 variants S8pAcF, S26pAcF, S71pAcF, S74pAcF, Q82pAcF, S85pAcF and PV3 variants S8pAcF, S26pAcF, S71pAcF, N77pAcF, S85pAcF, K87pAcF (Fig