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Researchers have used Acetyl L-Carnitine to help reverse peripheral nerve damage

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A series of barriers need to be circumvented for systemically administered exogenous siRNA before it can achieve gene silencing, 104,105,106 such as nuclease degradation and short-lived circulation, immune recognition in blood circulation, accumulation in desired tissue, effective transmembrane trafficking, and escape from endosomes and lysosomes to the cytoplasm