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Among B vitamins, while 5-methyltetrahydrofolate (5-MTHF) and vitamin B12 supplementation showed potential cellular benefits (Scambi et al., 2009), paradoxically high, often supra-physiological, serum B12 levels are frequently observed in highly supplemented children with pancreatic insufficiency (Maqbool et al., 2014)

Am J Physiol Endocrinol Metab (2009) 296:E132634

There are no adverse side effects with the doses used for skin brightening

Mouse grouping before the start of the experiments and mouse picking for data collection at the end were determined with an online random number generator ( Sample size estimation mainly depends on statistics