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Research has revealed that SAD reflects the convergence of multiple pathological processes, including chronic inflammation, mucus hypersecretion, epithelial-mesenchymal transition (EMT) and fibrotic remodeling, microvascular rarefaction, epithelial barrier dysfunction, and cellular senescence

This entailed four rotations of: a five-minute video with smoking-related content (composed of similar but non-identical clips to those presented in the baseline visit), a five-minute presentation of smoking images (with each image presented for 3 seconds, see Supplementary Methods), and five minutes of manipulating smoking paraphernalia (e.g., lighter, cigarettes)

Similarly, the exposure of the gas phase of cigarettes to human plasma cells results in the alteration of LDL in plasma (29)