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Once bound by SARS-CoV-2, the ACE2 expression (including mRNA level and enzyme activity) on the surface of host cells were significantly decreased, and then IL-6 in the toll-like receptor signaling pathway might influence the immune system as the downstream effector (, , )

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Thus, c v is the objective function, which usually refers to the growth rate of the organism and S v = 0 represents the balance of fluxes at steady state

And finally, further screening of other strains of Lactobacillus and genetic engineering of specific Lactobacillus strains should help in understanding and exploring their broader probiotic therapeutic role