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Acknowledgements This work was supported by National Natural Science Foundation of China (82405296, 82274483, 82305158) and Integrated Medicine Teamwork for Gastroenterology of the Nanjing University of Chinese Medicine (035062005006-40)

This suggests a possible positive selection in neoplastic cells for mutated mitochondrial genes, in keeping with observations that an aberrant mitochondrial respiration confers adaptive advantages to neurofibroma cells

Some studies suggest that supplementing with 3 mg of melatonin can help menopausal women who struggle with nighttime hot flashes regulate their body temperature