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Phase contrast micrographs for the other fourteen iPSC lines are shown in Supplementary Figure S1

In a clinical study conducted by Nordio et al., the effectiveness of myo-Ins-Se, which includes myo-inositol at a dose of 600 mg/day and selenium at a dose of 83 g/day, was examined in 86 patients with Hashimotos disease and subclinical hypothyroidism over a six-month period [41]

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Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease