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Doycheva D, Zierhut M, Blumenstock G, Stuebiger N, Januschowski K, Voykov B, et al

and Jin et al., showed that high concentrations of HNE (30-200 M) increased NLRP3 mRNA expression, IL-1, and IL-18 secretion in human ARPE-19 cells after LPS stimulation (60, 61)

Equally important is the development of biomarkers reflecting iron-handling capacity, lipid oxidative signatures, or ferroptosis-associated cytokine patterns to guide patient stratification and optimize therapy