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D., Weigel C., et al., Targeting Defective Sphingosine Kinase 1 in NiemannPick Type C Disease With an Activator Mitigates Cholesterol Accumulation, Journal of Biological Chemistry 295, no

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Apart from fingolimod, novel S1PR modulators are being developed, including ponesimod [66], siponimod [98], and CYM5442, as well as selective S1P1R antagonists, including W146, NIBR-14/15, and TASP0251078, as novel drug candidates for the treatment of various diseases, including multiple sclerosis, rheumatoid arthritis, colitis and cancer [99,100,101]