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Figure 1 It is noteworthy that the folate cycle functions in the cytosol and in the mitochondria, although most proliferating cells rely primarily on the mitochondrial pathway (Tibbetts and Appling, + which is necessary for glycolysis reactions (Ducker and Rabinowitz, Together the folate and methionine cycles mediate the redistribution of one-carbon groups derived from nutrients into the production of purine nucleotides (Tedeschi et al., 2017), ATP, and NADPH