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Mutations of IDH1/2 have been shown to promote self-renewal and suppress differentiation of normal HSCs, leading to the clonal expansion of stem/progenitor cells, known as pre-LSCs (67)

Another study found a higher prevalence of C677T polymorphism in BD patients than healthy subjects, while patients with BD with early onset carried one copy of the T allele 62

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Therefore, we monitored protein expression of TRX pathway components comparing human non-NE with NE cells as well as stickers with floaters