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Like the oxidative burst (where NADPH is required to drive the production of ROS from oxygen), defence against acute oxidative stress (where NADPH is required to drive the reduction in ROS to less reactive products like H 2 O) is also associated with a sudden, profound increase in NADPH demand

doi: 10.1158/1078-0432.CCR-17-3375 183 MohamedRFBakriHMEidS

TNF- inhibitors, including etanercept, infliximab, and adalimumab, represent the first class of biologics employed in psoriasis treatment, exhibiting substantial success in diminishing psoriatic plaques and enhancing quality of life (Megna et al

HTS can then be performed to screen large libraries of small molecules, peptides, or other compounds for their ability to interact with or modulate the activity of the GST-tagged protein