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US patent 0337024, Allison Coffin, Joseph Harding, Leen Kawas, Phillip Uribe, "Novel Lead Compound for Otoprotection: Targeting HGF Signaling with Dihexa", issued 2015-11-26 "Dihexa" (PDF)

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Molecular size also plays a role

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10.1124/dmd.113.054254 [DOI] [PubMed] [Google Scholar] Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., et al

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