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Description

Collectively, these clinical data substantiate the SNHG9 MAS regulatory axis and suggest that MAS upregulation during DILI may represent an adaptive response aimed at promoting hepatoprotective forms of autophagy, including mitophagy, thereby preserving hepatic homeostasis under hepatotoxic stress

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NRF2 /xc system/GPX4 axis Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor in the cellular antioxidant response (Owona and Schluesener, 2015)