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Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia

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The ingestion of these substances activates the AMPK enzyme, which leads to the burning of fats (oxidation) in the mitochondria and hence the production of energy (ATP) is increased

Activation of fatty acids to highly polar thiol esters, i.e., acyl-CoA, occurs on the outer mitochondrial membrane, but to enable transport across the inner mitochondrial membrane, the acyl group is transferred to carnitine with formation of acylcarnitines, which can enter the mitochondria with the assistance of translocases