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faecium has been observed which involves upregulation of plasmid-bound tet (L) and tet (M) genes encoding a major facilitator superfamily (MFS) efflux pump and ribosomal protection protein, respectively [142]

This finding shows that AS-IV's anti-inflammatory action on RTECs and inflammatory cells may be one of its potential pharmacological mechanisms to impede the course of renal fibrosis and CKD