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We speculate that the emergence of the N-terminal hydrophobic region in vertebrates reflects a domain-gain event during evolution, which enabled neofunctionalization towards roles in mediating endoplasmic reticulum (ER) stress responses 54 and facilitating physical contacts between the ER and mitochondria 55

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Acta Physiologiae Plantarum 34, 939946

Liraglutide 3.0 mgs efficacy in obesity was assessed in the Satiety and Clinical Adiposity-Liraglutide (SCALE) Obesity and Prediabetes and SCALE-diabetes trials [15,41]