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A yeast two-hybrid (Y2H) screen using cytoplasmic or luminal fragment of TMEM106B for bait and a prey library derived from human adult brain has identified TMEM106C, the endocytic adaptor proteins, AP2M1 and CLTC, and the vacuolar protein sorting proteins, VPS11 and VPS13D as N-terminal TMEM106B-binding proteins, although the functional importance of these interactions remains to be determined [134]

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(1) Ionescu M, Frohman LA (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog J Clin Endocrinol Metab