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While it is the overall diet or whole foods that mediate the impact on gut microbial composition, targeted effects might also be achieved through selected dietary-derived metabolites that are substrates for certain microbial species, an approach that underpins prebiotic development

The human body can produce it from amino acids found in protein-rich food, but production reduces if someone is on a calorie deficit, on a vegan or vegetarian diet or under intense physical stress

Based on the American Association of Poison Control Centers National Poison Data System, ~ 7,750 exposures to VPA including 119 severe and 2 fatal cases were reported in 2019 [2]