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These findings not only contribute novel insights but also provide a more comprehensive understanding of the pathophysiological mechanisms at play in cases of PE+

The results revealed that relative luciferase activity was significantly enhanced in cells transfected with MALAT1-wt and miR-155-5p inhibitor (Figure 3C) and was similarly increased in cells transfected with PAK2-wt and miR-155-5p inhibitor (Figure 3D)

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Moreover, Nrf2a key regulator of iron homeostasisis robustly activated by BL (Yao et al., 2020a,b), leading to increased production of NAD(P)H-dependent enzymes such as NQO1, suppression of NF-B signaling, and reduction of both -Syn aggregation and oxidative stressmediated neuroinflammatory damage (Lastres-Becker et al., 2016